Across TCGA cell cohorts, NPY2R mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NPY2R-associated genes across cancer lineages are SPINT4, RLN3, and CTAGE9. Each is linked with NPY2R in more than 1 cancer types. Because this analysis shows association rather than direction, both NPY2R-to-partner and partner-to-NPY2R results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPY2R→partner) and Y-score (partner→NPY2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPINT4 →	+0.042	+4.228	<.001	<.001	3	1
LUNG_NSCLC_LUAD	RLN3 →	+0.105	+4.415	.001	<.001	3	1
LUNG_NSCLC_LUAD	CTAGE9 →	+0.064	+3.409	.001	.009	3	1
SKIN	MYCL →	-0.541	-3.278	.007	.006	3	1
SKIN	PTMA →	+0.532	+3.064	.009	.009	3	1
SKIN	JMJD7 →	-0.713	-3.169	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

NPY2R survival (RNA) · tumor vs normal (RNA) · all NPY2R data types