NPTX2

Across TCGA cell cohorts, NPTX2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPTX2-associated genes across cancer lineages are OR2T4, CT45A6, and ANGPTL5. Each is linked with NPTX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPTX2-to-partner and partner-to-NPTX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T4 grouped by NPTX2-low versus NPTX2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPTX2→partner) and Y-score (partner→NPTX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2T4 →	+0.033	+5.807	<.001	.001	3	1
OVARY	CT45A6 →	+0.040	+5.196	.003	.005	3	1
BLOOD_Leukemia	ANGPTL5 →	+0.022	+4.276	.007	.007	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.104	+4.539	<.001	.007	3	1
BREAST	VCY1B →	+1.590	+4.421	<.001	.004	3	1
BREAST	NEUROD6 →	+0.005	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR2T4 by NPTX2 expression — OVARY

Explore this box plot interactively →