NPTX2

Across TCGA pan-cancer cohorts, NPTX2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NPTX2 data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NPTX2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NPTX2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and DLBC show a favorable association.

KIRP, UVM, and UCEC are the cancer types where NPTX2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.528	0.823	<.001	137	view →
UVM	OS	Quartile	All	0.401	0.897	.002	63	view →
UCEC	DFS	Median	All	0.785	0.890	<.001	36	view →
BLCA	DFS	Median	All	0.187	0.484	.009	24	view →
SKCM	OS	Tertile	III,IV	0.519	0.222	.002	16	view →
DLBC	DFS	Median	All	0.900	0.410	.010	15	view →
SCLC	OS	Quartile	II,III,IV	0.279	0.641	.024	14	view →
ACC	OS	Tertile	IV	0.785	0.333	.024	13	view →
KICH	OS	Median	III,IV	0.556	1.000	.010	12	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.836	.005	12	view →
SARC	OS	Median	All	0.424	0.590	.016	12	view →
LUAD	OS	Tertile	All	0.629	0.785	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NPTX2–KIRP (OS)

Open the KIRP breakdown →