NPTX2

Across TCGA pan-cancer cohorts, NPTX2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NPTX2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NPTX2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPTX2 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where NPTX2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPTX2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+5.567	<.001	12	view →
HNSC	All	III,IV	+0.998	<.001	11	view →
THCA	Male	All	+0.997	<.001	10	view →
LUAD	Female	All	+1.604	<.001	8	view →
COAD	All	II,III,IV	+1.417	<.001	6	view →
BRCA	Female	II,III,IV	+1.024	<.001	6	view →
LUSC	Female	All	+1.973	<.001	5	view →
UCEC	All	II,III,IV	+1.350	.007	4	view →
KIRP	All	All	+0.678	.006	4	view →
STAD	Female	All	−1.351	.004	3	view →
CHOL	All	All	+2.101	.019	1	view →
LIHC	All	II,III,IV	+0.519	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NPTX2–KIRC

Open the KIRC breakdown →