Across TCGA patient cohorts, NPS mutation is significantly associated with the RNA expression of many other genes, with 226 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NPS-associated genes across cancer lineages are RNA5SP206, RNU1-34P, and RBISP1. Each is linked with NPS in more than 1 cancer types. Because this analysis shows association rather than direction, both NPS-to-partner and partner-to-NPS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPS→partner) and Y-score (partner→NPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP206 →	+0.469	+4.463	<.001	.005	3	2
SKCM	RNU1-34P →	+0.144	+5.163	<.001	.002	3	2
SKCM	RBISP1 →	+0.098	+3.302	.002	.009	3	2
SKCM	LINC01201 →	+0.531	+4.897	<.001	.002	3	2
SKCM	LINC02641 →	+0.413	+3.430	<.001	.009	3	2
SKCM	SCAND3P1 →	+0.153	+3.265	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 226 associations by consensus.

Exploration

NPS survival (RNA) · tumor vs normal (RNA) · all NPS data types