Across TCGA pan-cancer cohorts, NPS RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of NPS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NPS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPS is over-expressed in tumor.

KIRC are the cancer types where NPS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.012	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: NPS RNA expression & survival · all NPS data types