NPR2

Across TCGA cell cohorts, NPR2 mutation is significantly associated with the RNA expression of many other genes, with 223 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPR2-associated genes across cancer lineages are TRIM49D2, GML, and PHOX2B. Each is linked with NPR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPR2-to-partner and partner-to-NPR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM49D2 grouped by NPR2-low versus NPR2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR2→partner) and Y-score (partner→NPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TRIM49D2 →	+0.040	+5.285	<.001	.003	3	1
BLOOD_Leukemia	GML →	+0.070	+2.982	<.001	.007	3	1
BLOOD_Leukemia	PHOX2B →	+0.017	+3.687	<.001	<.001	3	1
BLOOD_Leukemia	UCP1 →	+0.292	+3.321	<.001	.003	3	1
BLOOD_Leukemia	IL2 →	+0.574	+3.106	<.001	.005	3	1
BLOOD_Leukemia	GZMK →	+0.507	+3.359	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 223 associations by consensus.

TRIM49D2 by NPR2 expression — STOMACH

Explore this box plot interactively →