NPR2

Across TCGA pan-cancer cohorts, NPR2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NPR2’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where NPR2 RNA is repressed in tumor relative to normal tissue. In most cancer types NPR2 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and THCA are the cancer types where NPR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−2.345	<.001	8	view →
LUAD	Female	III,IV	−1.242	<.001	8	view →
THCA	Male	All	−0.739	<.001	7	view →
UCEC	All	III,IV	−2.142	<.001	6	view →
BRCA	All	III,IV	−1.461	<.001	6	view →
LIHC	Male	All	+1.011	<.001	5	view →
LUSC	All	All	−0.537	.005	4	view →
HNSC	Female	III,IV	+1.152	.020	3	view →
PRAD	All	All	−0.875	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NPR2–BLCA

Open the BLCA breakdown →