NPM2

Across TCGA patient cohorts, NPM2 mutation is significantly associated with the RNA expression of many other genes, with 525 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPM2-associated genes across cancer lineages are RNA5SP422, MIR548AN, and RNU6-1138P. Each is linked with NPM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPM2-to-partner and partner-to-NPM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP422 grouped by NPM2-low versus NPM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPM2→partner) and Y-score (partner→NPM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP422 →	+1.033	+2.256	<.001	.006	3	2
SKCM	MIR548AN →	+0.717	+3.803	.008	.003	3	2
COAD	RNU6-1138P →	+0.543	+4.790	<.001	.006	3	1
COAD	MIR580 →	+0.801	+4.354	<.001	.007	3	1
COAD	RNU6-1245P →	+0.538	+4.602	<.001	.008	3	1
COAD	HIGD1AP12 →	+0.277	+4.324	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 525 associations by consensus.

RNA5SP422 by NPM2 expression — UCEC

Explore this box plot interactively →