NPL

Across TCGA patient cohorts, NPL RNA expression is significantly associated with the protein abundance of many other proteins, with 16,285 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NPL-associated proteins across cancer lineages are ITGAX, HCK, and PLEK. Each is linked with NPL in more than 8 cancer types. Because this analysis shows association rather than direction, both NPL-to-partner and partner-to-NPL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPL versus ITGAX in UCEC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NPL→partner) and Y-score (partner→NPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGAX →	+0.722	+1.098	<.001	<.001	3	9
OV	HCK →	+0.599	+0.707	<.001	<.001	3	9
UCEC	PLEK →	+0.493	+0.744	<.001	<.001	3	9
GBM	PTPN6 →	+0.455	+0.553	<.001	<.001	3	8
COAD	PTPN7 →	+0.699	+0.901	<.001	<.001	3	8
UCEC	PTPRC →	+0.761	+0.846	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,285 associations by consensus.

NPL vs ITGAX — UCEC

Explore this scatter interactively →