NPL

Across TCGA patient cohorts, NPL mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPL-associated genes across cancer lineages are A-Raf_pS299, Heregulin, and JNK2. Each is linked with NPL in more than 1 cancer types. Because this analysis shows association rather than direction, both NPL-to-partner and partner-to-NPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by NPL-low versus NPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPL→partner) and Y-score (partner→NPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.126	-3.321	.013	.010	3	1
UCEC	Heregulin →	-0.148	-4.000	.004	<.001	3	1
UCEC	JNK2 →	+0.280	+2.834	<.001	.034	3	1
UCEC	Ku80 →	+0.289	+2.009	.003	.017	3	1
UCEC	MEK1 →	+0.361	+3.169	.019	.018	3	1
UCEC	MSH2 →	-0.262	-2.973	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

A-Raf_pS299 by NPL expression — UCEC

Explore this box plot interactively →