NPIPB7

Across TCGA patient cohorts, NPIPB7 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPIPB7-associated genes across cancer lineages are CYP11B2, OR51D1, and RNU6-391P. Each is linked with NPIPB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPIPB7-to-partner and partner-to-NPIPB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP11B2 grouped by NPIPB7-low versus NPIPB7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPIPB7→partner) and Y-score (partner→NPIPB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYP11B2 →	+0.053	+3.719	.007	.008	3	1
UCEC	OR51D1 →	+0.188	+3.719	<.001	.008	3	1
UCEC	RNU6-391P →	+0.457	+4.442	<.001	.007	3	1
UCEC	RNU6-767P →	+0.558	+3.871	.006	.006	3	1
UCEC	RNU6-886P →	+0.744	+4.073	<.001	.004	3	1
UCEC	RPS29P31 →	+0.512	+4.393	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

CYP11B2 by NPIPB7 expression — UCEC

Explore this box plot interactively →