NPIPB12

Across TCGA patient cohorts, NPIPB12 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible NPIPB12-associated genes across cancer lineages are H2AB2, LINC02336, and RBMY1F. Each is linked with NPIPB12 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPIPB12-to-partner and partner-to-NPIPB12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AB2 grouped by NPIPB12-low versus NPIPB12-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPIPB12→partner) and Y-score (partner→NPIPB12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	H2AB2 →	+0.089	+8.057	<.001	.005	3	1
BRCA	LINC02336 →	+0.096	+7.471	<.001	.008	3	1
BRCA	RBMY1F →	+0.016	+8.057	<.001	.005	3	1
BRCA	LINC02429 →	+0.078	+7.586	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

H2AB2 by NPIPB12 expression — BRCA

Explore this box plot interactively →