NPIPB12

Across TCGA pan-cancer cohorts, NPIPB12 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of NPIPB12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NPIPB12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPIPB12 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, STAD, and COAD are the cancer types where NPIPB12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPIPB12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.080	<.001	8	view →
STAD	All	II,III,IV	+0.376	.001	5	view →
COAD	Female	IV	+0.280	.010	4	view →
READ	All	II,III,IV	+0.265	.002	4	view →
LIHC	All	All	+0.033	.009	4	view →
HNSC	Male	All	+0.051	.003	3	view →
LUSC	All	All	−0.085	.008	1	view →
KICH	Female	III,IV	+0.066	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

NPIPB12–KIRC

Open the KIRC breakdown →