NPHP4

Across TCGA patient cohorts, NPHP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,164 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible NPHP4-associated GO terms across cancer lineages are Cytoskeleton-dependent intracellular transport, Microtubule anchoring, and Smoothened signaling pathway. Each is linked with NPHP4 in more than 32 cancer types. Because this analysis shows association rather than direction, both NPHP4-to-partner and partner-to-NPHP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoskeleton-dependent intracellular transport grouped by NPHP4-low versus NPHP4-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP4→partner) and Y-score (partner→NPHP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Cytoskeleton-dependent intracellular transport →	+0.073	+1.030	<.001	<.001	3	32
SCLC	Microtubule anchoring →	+0.091	+0.959	<.001	<.001	3	32
UCS	Smoothened signaling pathway →	+0.045	+0.920	.001	.005	1	33
SCLC	Cytokinesis →	+0.061	+0.857	<.001	<.001	3	31
SCLC	Regulation of cilium assembly →	+0.063	+0.981	<.001	<.001	3	31
SCLC	Positive regulation of organelle assembly →	+0.082	+0.952	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,164 associations by consensus.

Cytoskeleton-dependent intracellular transport by NPHP4 expression — SCLC

Explore this box plot interactively →