NPHP4

Across TCGA pan-cancer cohorts, NPHP4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NPHP4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NPHP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPHP4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, HNSC, and BLCA are the cancer types where NPHP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPHP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.097	<.001	11	view →
HNSC	Male	All	+0.799	<.001	11	view →
BLCA	Female	All	+0.826	<.001	10	view →
KICH	Male	All	−1.514	<.001	8	view →
STAD	Male	II,III,IV	+1.056	<.001	8	view →
LIHC	All	II,III,IV	+0.404	.001	6	view →
ESCA	All	II,III,IV	+1.055	.001	5	view →
PAAD	All	All	+0.532	.001	4	view →
CHOL	All	All	+1.367	<.001	3	view →
READ	Female	All	+0.786	.003	2	view →
KIRP	All	IV	+0.587	.018	2	view →
BRCA	All	IV	+0.415	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NPHP4–COAD

Open the COAD breakdown →