NPHP4

Across TCGA pan-cancer cohorts, NPHP4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated NPHP4 data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NPHP4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPHP4 expression acts as an unfavorable survival marker, although some lineages such as SCLC and HNSC show a favorable association.

ACC, LUSC, and KICH are the cancer types where NPHP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.511	0.805	<.001	117	view →
LUSC	DFS	Quartile	III,IV	0.521	0.859	.002	41	view →
KICH	DFS	Median	III,IV	0.240	1.000	.001	37	view →
BLCA	DFS	Tertile	All	0.259	0.504	.010	33	view →
LGG	DFS	Median	All	0.661	0.818	<.001	29	view →
SCLC	OS	Quartile	All	0.552	0.208	.008	28	view →
HNSC	DFS	Tertile	IV	0.563	0.321	.008	20	view →
SARC	OS	Median	All	0.398	0.611	<.001	18	view →
LIHC	OS	Quartile	II,III,IV	0.298	0.592	.016	17	view →
STAD	OS	Tertile	All	0.775	0.571	.001	14	view →
SKCM	OS	Quartile	All	0.692	0.817	.003	13	view →
UCS	OS	Tertile	IV	0.675	0.206	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

NPHP4–ACC (DFS)

Open the ACC breakdown →