NPHP4

Across TCGA patient cohorts, NPHP4 mutation is significantly associated with the RNA expression of many other genes, with 5,035 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPHP4-associated genes across cancer lineages are B3GNT4, GCAT, and PLTP. Each is linked with NPHP4 in more than 3 cancer types. Because this analysis shows association rather than direction, both NPHP4-to-partner and partner-to-NPHP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B3GNT4 grouped by NPHP4-low versus NPHP4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP4→partner) and Y-score (partner→NPHP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	B3GNT4 →	+0.423	+2.662	<.001	<.001	3	4
UCEC	GCAT →	+0.564	+1.392	<.001	<.001	3	4
UCEC	PLTP →	-0.649	-1.728	<.001	<.001	3	4
COAD	C21orf62-AS1 →	-0.281	-2.866	.001	.001	3	4
COAD	MTFP1 →	+0.516	+2.196	<.001	.001	3	4
COAD	RN7SL472P →	+0.407	+2.354	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,035 associations by consensus.

B3GNT4 by NPHP4 expression — COAD

Explore this box plot interactively →