NPHP4

Across TCGA patient cohorts, NPHP4 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPHP4-associated genes across cancer lineages are GAPDH, ATM, and PKC-delta_pS664. Each is linked with NPHP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPHP4-to-partner and partner-to-NPHP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by NPHP4-low versus NPHP4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP4→partner) and Y-score (partner→NPHP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.568	+3.169	.001	.017	3	3
COAD	ATM →	-0.448	-2.459	.001	.017	3	3
COAD	PKC-delta_pS664 →	-0.132	-2.442	.006	.017	3	3
COAD	Rad50 →	-0.256	-2.459	.003	.017	3	3
COAD	Caspase-7-cleavedD198 →	+1.469	+2.423	<.001	.001	3	3
UCEC	p53 →	-0.252	-1.584	.013	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

GAPDH by NPHP4 expression — COAD

Explore this box plot interactively →