NPHP4

Across TCGA cell cohorts, NPHP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,632 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NPHP4-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Negative regulation of transcription initiation by RNA polymerase II, and Regulation of DNA repair. Each is linked with NPHP4 in more than 15 cancer types. Because this analysis shows association rather than direction, both NPHP4-to-partner and partner-to-NPHP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by NPHP4-low versus NPHP4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP4→partner) and Y-score (partner→NPHP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.133	+0.928	<.001	<.001	3	16
BONE	Negative regulation of transcription initiation by RNA polymerase II →	+0.156	+1.372	<.001	<.001	3	15
BONE	Regulation of DNA repair →	+0.101	+1.230	<.001	.004	3	15
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.146	+0.997	<.001	<.001	3	15
BREAST	Negative regulation of sister chromatid cohesion →	+0.099	+1.139	<.001	<.001	3	15
BONE	Nucleic acid transport →	+0.173	+1.617	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,632 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by NPHP4 expression — BONE

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