NPHP4

Across TCGA cell cohorts, NPHP4 mutation is significantly associated with the RNA expression of many other genes, with 1,156 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPHP4-associated genes across cancer lineages are OPRPN, TARM1, and OOSP4A. Each is linked with NPHP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPHP4-to-partner and partner-to-NPHP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by NPHP4-low versus NPHP4-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP4→partner) and Y-score (partner→NPHP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPRPN →	+0.045	+4.087	<.001	.009	3	1
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	1
SOFT_TISSUE	OOSP4A →	+0.067	+4.930	<.001	.008	3	1
BREAST	TMEM207 →	+0.162	+4.672	<.001	.002	3	1
BREAST	KRT25 →	+0.098	+4.421	<.001	.004	3	1
BREAST	NMRK2 →	+0.039	+4.199	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,156 associations by consensus.

OPRPN by NPHP4 expression — URINARY_TRACT

Explore this box plot interactively →