NPHP3-ACAD11

Across TCGA patient cohorts, NPHP3-ACAD11 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,124 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NPHP3-ACAD11-associated proteins across cancer lineages are CARD9_S460, CD44_S697, and HDGFL2_S240. Each is linked with NPHP3-ACAD11 in more than 3 cancer types. Because this analysis shows association rather than direction, both NPHP3-ACAD11-to-partner and partner-to-NPHP3-ACAD11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPHP3-ACAD11 versus CARD9_S460 in CCRCC, with a Pearson correlation of -0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP3-ACAD11→partner) and Y-score (partner→NPHP3-ACAD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CARD9_S460 →	-0.597	-0.250	.002	.006	3	4
CCRCC	CD44_S697 →	-0.559	-0.240	.008	.003	3	3
LSCC	HDGFL2_S240 →	+2.257	+0.072	<.001	<.001	3	3
LSCC	ARHGEF6_S225 →	-0.474	-0.046	.002	.004	3	3
GBM	PTPRC_S994 →	-0.869	-0.047	.005	.004	3	3
OV	CENPI →	+0.719	+0.053	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,124 associations by consensus.

NPHP3-ACAD11 vs CARD9_S460 — CCRCC

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