NPHP3-ACAD11

Across TCGA pan-cancer cohorts, NPHP3-ACAD11 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of NPHP3-ACAD11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NPHP3-ACAD11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPHP3-ACAD11 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where NPHP3-ACAD11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPHP3-ACAD11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.013	<.001	9	view →
HNSC	All	All	+0.011	.003	8	view →
KICH	Female	All	−0.030	.004	3	view →
BLCA	All	All	+0.027	.018	3	view →
LUSC	All	All	+0.018	.001	2	view →
THCA	Female	All	−0.015	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

NPHP3-ACAD11–KIRC

Open the KIRC breakdown →