NPHP3-ACAD11

Across TCGA pan-cancer cohorts, NPHP3-ACAD11 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NPHP3-ACAD11 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NPHP3-ACAD11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPHP3-ACAD11 expression acts as an unfavorable survival marker, although some lineages such as READ and GBM show a favorable association.

KIRC, ACC, and READ are the cancer types where NPHP3-ACAD11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.379	0.605	.003	32	view →
ACC	OS	Quartile	All	0.286	0.794	<.001	22	view →
READ	OS	Median	IV	1.000	0.520	.011	21	view →
STAD	DFS	Tertile	III,IV	0.360	0.526	.025	17	view →
COAD	OS	Median	All	0.440	0.639	.002	14	view →
MESO	DFS	Median	III,IV	0.267	0.495	.003	13	view →
GBM	OS	Median	All	0.543	0.304	.006	13	view →
UCS	DFS	Tertile	IV	0.981	0.459	.024	12	view →
ESCA	OS	Quartile	IV	0.095	0.545	.045	12	view →
PCPG	OS	Tertile	All	0.885	1.000	.009	11	view →
LGG	OS	Quartile	All	0.857	0.703	.021	6	view →
THYM	DFS	Tertile	III,IV	1.000	0.419	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NPHP3-ACAD11–KIRC (DFS)

Open the KIRC breakdown →