NPC2

Across TCGA cell cohorts, NPC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,778 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NPC2-associated GO terms across cancer lineages are Protein catabolic process at synapse, Protein catabolic process at postsynapse, and Protein targeting to lysosome involved in chaperone-mediated autophagy. Each is linked with NPC2 in more than 12 cancer types. Because this analysis shows association rather than direction, both NPC2-to-partner and partner-to-NPC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein catabolic process at synapse grouped by NPC2-low versus NPC2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC2→partner) and Y-score (partner→NPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Protein catabolic process at synapse →	+0.178	+1.453	.002	<.001	3	12
STOMACH	Protein catabolic process at postsynapse →	+0.178	+1.453	.002	<.001	3	12
BONE	Protein targeting to lysosome involved in chaperone-mediated autophagy →	+0.198	+1.848	.004	<.001	2	13
BONE	'de novo' AMP biosynthetic process →	-0.163	-1.521	<.001	<.001	3	11
LARGE_INTESTINE	IMP biosynthetic process →	-0.163	-1.161	<.001	<.001	2	12
BONE	'de novo' IMP biosynthetic process →	-0.153	-1.541	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,778 associations by consensus.

Protein catabolic process at synapse by NPC2 expression — STOMACH

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