NPAS4

Across TCGA cell cohorts, NPAS4 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPAS4-associated genes across cancer lineages are GAGE12E, UTF1, and C14orf180. Each is linked with NPAS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPAS4-to-partner and partner-to-NPAS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12E grouped by NPAS4-low versus NPAS4-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPAS4→partner) and Y-score (partner→NPAS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12E →	+0.076	+4.643	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.170	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	C14orf180 →	+0.006	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	CENPVL1 →	+0.040	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	USP17L22 →	+0.010	+4.357	<.001	.006	3	1
OVARY	CGB3 →	+0.792	+4.000	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

GAGE12E by NPAS4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →