NPAS4

Across TCGA pan-cancer cohorts, NPAS4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NPAS4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NPAS4 RNA is repressed in tumor relative to normal tissue. In most cancer types NPAS4 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, STAD, and KICH are the cancer types where NPAS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPAS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.424	<.001	8	view →
STAD	All	All	−0.761	<.001	7	view →
KICH	All	All	−0.165	<.001	7	view →
UCEC	All	All	−1.487	<.001	6	view →
BLCA	Male	IV	−1.237	<.001	6	view →
BRCA	All	III,IV	−0.471	<.001	6	view →
KIRP	All	All	−0.121	<.001	6	view →
KIRC	Male	II,III,IV	−0.056	.004	5	view →
READ	All	III,IV	−0.715	.003	4	view →
THCA	Female	All	−0.076	.005	4	view →
PRAD	All	All	−0.366	<.001	2	view →
LUAD	Female	All	−0.075	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NPAS4–COAD

Open the COAD breakdown →