NOVA1

Across TCGA patient cohorts, NOVA1 mutation is significantly associated with the RNA expression of many other genes, with 4,677 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOVA1-associated genes across cancer lineages are PTBP1, KHSRP, and SKA3. Each is linked with NOVA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NOVA1-to-partner and partner-to-NOVA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTBP1 grouped by NOVA1-low versus NOVA1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOVA1→partner) and Y-score (partner→NOVA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PTBP1 →	+0.377	+2.608	.003	.006	3	4
LUSC	KHSRP →	+0.499	+3.193	.004	.009	3	4
UCEC	SKA3 →	+0.603	+1.362	<.001	<.001	3	4
UCEC	CHAF1A →	+0.576	+1.954	<.001	<.001	3	4
UCEC	POLE →	+0.407	+1.718	<.001	.001	3	4
SKCM	AURKB →	+0.573	+1.807	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,677 associations by consensus.

PTBP1 by NOVA1 expression — LUSC

Explore this box plot interactively →