NOVA1

Across TCGA pan-cancer cohorts, NOVA1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of NOVA1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where NOVA1 RNA is repressed in tumor relative to normal tissue. In most cancer types NOVA1 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and READ are the cancer types where NOVA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOVA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−2.200	<.001	11	view →
COAD	Male	II,III,IV	−1.164	<.001	11	view →
READ	Female	All	−1.789	<.001	7	view →
UCEC	All	III,IV	−1.916	<.001	6	view →
BRCA	Female	II,III,IV	−1.804	<.001	6	view →
KIRP	Male	II,III,IV	+0.670	.013	5	view →
LIHC	All	All	+0.384	<.001	4	view →
HNSC	All	All	−0.333	.003	4	view →
STAD	All	All	−0.803	.004	3	view →
KICH	All	All	−0.590	.006	3	view →
THCA	Male	II,III,IV	−0.607	<.001	2	view →
LUSC	Female	All	−0.464	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

NOVA1–BLCA

Open the BLCA breakdown →