NOTCH3

Across TCGA patient cohorts, NOTCH3 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOTCH3-associated genes across cancer lineages are C-Raf, ASNS, and BRCA2. Each is linked with NOTCH3 in more than 4 cancer types. Because this analysis shows association rather than direction, both NOTCH3-to-partner and partner-to-NOTCH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by NOTCH3-low versus NOTCH3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH3→partner) and Y-score (partner→NOTCH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	C-Raf →	+0.162	+3.321	.012	.009	3	5
STAD	ASNS →	+0.425	+3.169	.018	.018	3	4
STAD	BRCA2 →	-0.141	-3.786	.014	<.001	3	4
UCEC	Cyclin-B1 →	+0.450	+2.584	.002	<.001	3	4
COAD	Cyclin-E2 →	+0.191	+3.195	.043	.009	3	4
UCEC	eEF2 →	+0.277	+1.440	.004	.020	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

C-Raf by NOTCH3 expression — STAD

Explore this box plot interactively →