NOTCH3

Across TCGA pan-cancer cohorts, NOTCH3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NOTCH3 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NOTCH3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NOTCH3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

KIRP, UVM, and HNSC are the cancer types where NOTCH3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.525	0.806	<.001	123	view →
UVM	DFS	Median	All	0.426	0.718	<.001	108	view →
HNSC	DFS	Tertile	IV	0.756	0.513	<.001	98	view →
MESO	OS	Median	All	0.281	0.487	.001	66	view →
BLCA	OS	Quartile	II,III,IV	0.321	0.575	.003	64	view →
COAD	DFS	Quartile	All	0.583	0.763	<.001	45	view →
UCS	DFS	Median	IV	0.952	0.367	.001	38	view →
LGG	OS	Tertile	All	0.377	0.528	<.001	35	view →
THYM	DFS	Median	All	0.882	0.613	.002	28	view →
STAD	DFS	Median	II,III,IV	0.388	0.609	.020	25	view →
SKCM	OS	Quartile	All	0.257	0.425	<.001	24	view →
UCEC	DFS	Quartile	IV	0.864	0.273	.015	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NOTCH3–KIRP (OS)

Open the KIRP breakdown →