NOTCH2NLA

Across TCGA patient cohorts, NOTCH2NLA RNA expression is significantly associated with the go_rna of many other GO terms, with 7,157 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible NOTCH2NLA-associated GO terms across cancer lineages are Membrane protein proteolysis, Phosphatidylinositol dephosphorylation, and Endosome organization. Each is linked with NOTCH2NLA in more than 32 cancer types. Because this analysis shows association rather than direction, both NOTCH2NLA-to-partner and partner-to-NOTCH2NLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane protein proteolysis grouped by NOTCH2NLA-low versus NOTCH2NLA-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH2NLA→partner) and Y-score (partner→NOTCH2NLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Membrane protein proteolysis →	+0.117	+1.651	<.001	<.001	3	32
ESCA	Phosphatidylinositol dephosphorylation →	+0.063	+0.242	<.001	<.001	3	32
SCLC	Endosome organization →	+0.068	+1.314	<.001	.002	3	32
SCLC	Adipose tissue development →	+0.119	+1.463	<.001	<.001	3	32
SCLC	Endosomal transport →	+0.069	+1.024	.003	.005	1	33
DLBC	Golgi to endosome transport →	+0.066	+0.057	.002	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,157 associations by consensus.

Membrane protein proteolysis by NOTCH2NLA expression — SCLC

Explore this box plot interactively →