NOTCH2NLA

Across TCGA pan-cancer cohorts, NOTCH2NLA RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NOTCH2NLA data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NOTCH2NLA RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOTCH2NLA expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

ACC, KIRC, and UVM are the cancer types where NOTCH2NLA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Quartile	All	0.445	0.792	<.001	77	view →
KIRC	DFS	Tertile	All	0.808	0.500	<.001	70	view →
UVM	OS	Median	III,IV	0.637	0.948	.003	47	view →
OV	OS	Tertile	III,IV	0.291	0.396	.006	46	view →
MESO	OS	Median	III,IV	0.258	0.750	.002	39	view →
CESC	DFS	Tertile	III,IV	0.445	0.842	.005	26	view →
BRCA	DFS	Tertile	III,IV	0.603	0.280	.001	23	view →
LUSC	DFS	Tertile	III,IV	0.405	1.000	.003	19	view →
SKCM	OS	Quartile	III,IV	0.786	0.575	.003	19	view →
DLBC	DFS	Median	II,III,IV	0.580	1.000	.013	11	view →
BLCA	OS	Median	All	0.235	0.557	.023	10	view →
PRAD	DFS	Tertile	All	0.964	0.901	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NOTCH2NLA–ACC (DFS)

Open the ACC breakdown →