NOTCH2NLA

Across TCGA pan-cancer cohorts, NOTCH2NLA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NOTCH2NLA’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NOTCH2NLA RNA is repressed in tumor relative to normal tissue. In most cancer types NOTCH2NLA is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and UCEC are the cancer types where NOTCH2NLA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOTCH2NLA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.235	<.001	9	view →
KICH	All	All	−0.254	<.001	8	view →
UCEC	All	II,III,IV	−0.222	<.001	8	view →
LUSC	All	II,III,IV	−0.193	<.001	7	view →
COAD	All	II,III,IV	−0.053	<.001	7	view →
KIRC	All	All	−0.075	.007	5	view →
CHOL	All	All	+0.155	.003	3	view →
READ	All	III,IV	−0.135	.006	3	view →
HNSC	Female	II,III,IV	+0.052	.022	3	view →
LIHC	All	All	+0.051	.004	3	view →
STAD	All	IV	+0.203	.031	1	view →
LUAD	Female	II,III,IV	−0.115	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NOTCH2NLA–THCA

Open the THCA breakdown →