NOTCH2NLA

Across TCGA cell cohorts, NOTCH2NLA mutation is significantly associated with the mutation status of many other genes, with 641 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOTCH2NLA-associated genes across cancer lineages are LANCL2, ANKEF1, and RPS6KA5. Each is linked with NOTCH2NLA in more than 2 cancer types. Because this analysis shows association rather than direction, both NOTCH2NLA-to-partner and partner-to-NOTCH2NLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LANCL2 grouped by NOTCH2NLA-low versus NOTCH2NLA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH2NLA→partner) and Y-score (partner→NOTCH2NLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LANCL2 →	+4.087	+5.044	.001	.001	1	3
BLOOD_Lymphoma	ANKEF1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Leukemia	RPS6KA5 →	+4.736	+5.560	.003	.003	1	3
BLOOD_Leukemia	POLG2 →	+6.321	+6.321	.001	.001	1	2
BLOOD_Leukemia	MEP1A →	+4.000	+5.050	.008	.008	1	2
BLOOD_Leukemia	PCDHB10 →	+4.000	+5.050	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 641 associations by consensus.

LANCL2 by NOTCH2NLA expression — LARGE_INTESTINE

Explore this box plot interactively →