NOTCH2

Across TCGA cell cohorts, NOTCH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,286 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NOTCH2-associated GO terms across cancer lineages are Regulation of focal adhesion assembly, Regulation of cell-substrate junction assembly, and Podocyte development. Each is linked with NOTCH2 in more than 16 cancer types. Because this analysis shows association rather than direction, both NOTCH2-to-partner and partner-to-NOTCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of focal adhesion assembly grouped by NOTCH2-low versus NOTCH2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH2→partner) and Y-score (partner→NOTCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of focal adhesion assembly →	+0.220	+1.844	<.001	<.001	3	17
BONE	Regulation of cell-substrate junction assembly →	+0.220	+1.844	<.001	<.001	3	17
BONE	Podocyte development →	+0.338	+1.877	<.001	<.001	3	16
BONE	Glomerular epithelial cell development →	+0.364	+2.048	<.001	<.001	3	16
BONE	Regulation of cell-substrate junction organization →	+0.125	+1.274	<.001	<.001	3	16
BONE	Positive regulation of focal adhesion assembly →	+0.237	+1.500	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,286 associations by consensus.

Regulation of focal adhesion assembly by NOTCH2 expression — BONE

Explore this box plot interactively →