NOTCH2

Across TCGA pan-cancer cohorts, NOTCH2 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of NOTCH2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where NOTCH2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NOTCH2 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRP, KICH, and CHOL are the cancer types where NOTCH2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOTCH2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+1.151	.001	9	view →
KICH	Female	II,III,IV	−2.399	<.001	8	view →
CHOL	All	All	+1.900	<.001	3	view →
KIRC	All	All	+0.309	.007	3	view →
UCEC	All	All	−1.073	<.001	2	view →
COAD	Female	IV	−0.614	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

NOTCH2–KIRP

Open the KIRP breakdown →