NOTCH2

Across TCGA pan-cancer cohorts, NOTCH2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated NOTCH2 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NOTCH2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOTCH2 expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCS show a favorable association.

ACC, BLCA, and ESCA are the cancer types where NOTCH2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.404	0.757	<.001	90	view →
BLCA	OS	Quartile	II,III,IV	0.500	0.712	<.001	57	view →
ESCA	OS	Tertile	III,IV	0.717	0.251	<.001	52	view →
MESO	DFS	Quartile	II,III,IV	0.284	0.564	.009	38	view →
UCS	DFS	Quartile	II,III,IV	0.716	0.214	.003	38	view →
KIRC	DFS	Median	All	0.868	0.722	.001	35	view →
LGG	OS	Quartile	All	0.370	0.685	<.001	26	view →
STAD	DFS	Quartile	All	0.561	0.875	.005	22	view →
UCEC	DFS	Quartile	All	0.596	0.752	.001	22	view →
LUSC	DFS	Median	III,IV	0.434	0.884	.009	21	view →
HNSC	DFS	Quartile	All	0.781	0.615	.003	20	view →
OV	OS	Quartile	II,III,IV	0.298	0.410	.023	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

NOTCH2–ACC (DFS)

Open the ACC breakdown →