NOTCH2

Across TCGA cell cohorts, NOTCH2 mutation is significantly associated with the RNA expression of many other genes, with 1,841 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOTCH2-associated genes across cancer lineages are ZNF445, TRIM49C, and SERPINA12. Each is linked with NOTCH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOTCH2-to-partner and partner-to-NOTCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF445 grouped by NOTCH2-low versus NOTCH2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH2→partner) and Y-score (partner→NOTCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF445 →	+0.479	+2.158	.003	.004	3	3
URINARY_TRACT	TRIM49C →	+0.005	+4.087	<.001	.009	3	2
PANCREAS	SERPINA12 →	+0.012	+4.614	<.001	.004	3	2
LUNG_NSCLC_LUSC	NOBOX →	+0.040	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	USP17L11 →	+0.090	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	KIR2DL3 →	+0.043	+4.643	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,841 associations by consensus.

ZNF445 by NOTCH2 expression — LARGE_INTESTINE

Explore this box plot interactively →