NOP53

Across TCGA patient cohorts, NOP53 mutation is significantly associated with the RNA expression of many other genes, with 431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOP53-associated genes across cancer lineages are RN7SL248P, DEFB105A, and RPL9P13. Each is linked with NOP53 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOP53-to-partner and partner-to-NOP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by NOP53-low versus NOP53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP53→partner) and Y-score (partner→NOP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.079	+3.500	<.001	.002	3	2
LGG	DEFB105A →	+0.134	+7.977	<.001	.007	3	2
LUSC	RPL9P13 →	+0.079	+4.496	.001	.007	3	2
LUSC	ELOA3BP →	+0.023	+6.333	<.001	<.001	3	2
SKCM	OOSP1P1 →	+0.120	+4.265	<.001	.001	3	2
BLCA	RNA5SP183 →	+0.462	+5.177	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 431 associations by consensus.

RN7SL248P by NOP53 expression — UCEC

Explore this box plot interactively →