NOP16

Across TCGA patient cohorts, NOP16 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOP16-associated genes across cancer lineages are PLCE1P1, RNU5F-6P, and RNU6-215P. Each is linked with NOP16 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOP16-to-partner and partner-to-NOP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLCE1P1 grouped by NOP16-low versus NOP16-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP16→partner) and Y-score (partner→NOP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLCE1P1 →	+0.118	+7.731	<.001	.009	3	1
BRCA	RNU5F-6P →	+0.278	+7.731	<.001	.009	3	1
BRCA	RNU6-215P →	+0.307	+7.731	<.001	.009	3	1
BRCA	RNA5SP377 →	+0.288	+8.471	<.001	.005	3	1
BRCA	RNU6-860P →	+0.308	+8.055	<.001	.007	3	1
BRCA	TAAR7P →	+0.147	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

PLCE1P1 by NOP16 expression — BRCA

Explore this box plot interactively →