NOP16

Across TCGA pan-cancer cohorts, NOP16 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NOP16’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NOP16 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NOP16 is over-expressed in tumor.

KIRC, COAD, and LIHC are the cancer types where NOP16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOP16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.240	<.001	12	view →
COAD	Female	II,III,IV	+1.525	<.001	11	view →
LIHC	Male	II,III,IV	+1.208	<.001	9	view →
KIRP	Male	III,IV	+1.026	<.001	9	view →
STAD	All	II,III,IV	+0.948	<.001	9	view →
LUSC	All	III,IV	+1.589	<.001	8	view →
LUAD	Female	III,IV	+1.303	<.001	8	view →
BLCA	Male	III,IV	+1.238	.002	7	view →
UCEC	All	III,IV	+1.206	<.001	6	view →
BRCA	All	All	+0.483	<.001	6	view →
CHOL	All	All	+1.803	<.001	5	view →
READ	All	All	+1.078	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NOP16–KIRC

Open the KIRC breakdown →