NOP10

Across TCGA cell cohorts, NOP10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,505 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NOP10-associated GO terms across cancer lineages are [2Fe-2S] cluster assembly, snoRNA guided rRNA pseudouridine synthesis, and Pre-mRNA catabolic process. Each is linked with NOP10 in more than 12 cancer types. Because this analysis shows association rather than direction, both NOP10-to-partner and partner-to-NOP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, [2Fe-2S] cluster assembly grouped by NOP10-low versus NOP10-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP10→partner) and Y-score (partner→NOP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	[2Fe-2S] cluster assembly →	+0.110	+0.571	.001	.007	2	13
UPPER_AERODIGESTIVE_TRACT	snoRNA guided rRNA pseudouridine synthesis →	+0.100	+1.049	<.001	<.001	3	11
BONE	Pre-mRNA catabolic process →	-0.199	-0.788	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	tRNA 5'-end processing →	+0.126	+0.969	<.001	<.001	3	10
BONE	Regulation of protein import into nucleus →	-0.061	-0.658	.001	.001	3	10
KIDNEY	DAMP biosynthetic process →	+0.183	+0.768	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,505 associations by consensus.

[2Fe-2S] cluster assembly by NOP10 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →