NOP10

Across TCGA pan-cancer cohorts, NOP10 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NOP10 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NOP10 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOP10 expression acts as an unfavorable survival marker, although some lineages such as UCEC and MESO show a favorable association.

UVM, ACC, and HNSC are the cancer types where NOP10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.414	0.747	<.001	145	view →
ACC	DFS	Tertile	All	0.254	0.780	<.001	72	view →
HNSC	DFS	Tertile	All	0.601	0.745	<.001	70	view →
LIHC	OS	Median	All	0.613	0.758	<.001	69	view →
KICH	DFS	Tertile	All	0.665	1.000	.002	58	view →
UCEC	OS	Tertile	III,IV	0.708	0.294	.001	56	view →
UCS	DFS	Median	IV	0.367	0.952	.001	48	view →
SKCM	DFS	Median	All	0.657	0.847	<.001	48	view →
PAAD	DFS	Median	All	0.253	0.505	.002	45	view →
LAML	DFS	Median	All	0.358	0.567	<.001	40	view →
LGG	OS	Tertile	All	0.708	0.864	<.001	36	view →
SCLC	DFS	Quartile	II,III,IV	0.385	0.763	.004	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NOP10–UVM (DFS)

Open the UVM breakdown →