NOP10

Across TCGA pan-cancer cohorts, NOP10 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NOP10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NOP10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NOP10 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where NOP10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOP10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.081	<.001	12	view →
KIRC	Female	IV	+0.735	<.001	12	view →
BLCA	All	All	+0.775	<.001	10	view →
LIHC	Male	III,IV	+1.146	<.001	9	view →
UCEC	All	All	+0.599	<.001	6	view →
KIRP	All	All	+0.369	<.001	6	view →
BRCA	All	All	+0.236	<.001	6	view →
CHOL	Male	All	+1.631	<.001	5	view →
STAD	All	All	+0.513	<.001	5	view →
COAD	Female	II,III,IV	+0.540	<.001	4	view →
ESCA	All	All	+1.075	.008	2	view →
KICH	All	All	−0.329	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NOP10–HNSC

Open the HNSC breakdown →