NODAL

Across TCGA patient cohorts, NODAL RNA expression is significantly associated with the protein abundance of many other proteins, with 13,482 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NODAL-associated proteins across cancer lineages are GATAD2B, HCFC1, and POGK. Each is linked with NODAL in more than 4 cancer types. Because this analysis shows association rather than direction, both NODAL-to-partner and partner-to-NODAL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NODAL versus GATAD2B in LSCC, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NODAL→partner) and Y-score (partner→NODAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GATAD2B →	+0.349	+0.541	<.001	<.001	3	5
HNSC	HCFC1 →	+0.225	+0.574	<.001	.002	3	5
HNSC	POGK →	+0.292	+0.468	<.001	<.001	3	4
GBM	PPP1CC →	+0.272	+0.523	<.001	<.001	3	4
GBM	RPS6KA1 →	-0.287	-0.393	<.001	.003	3	4
HNSC	HNRNPU →	+0.273	+0.832	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,482 associations by consensus.

NODAL vs GATAD2B — LSCC

Explore this scatter interactively →