NODAL

Across TCGA pan-cancer cohorts, NODAL RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated NODAL data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NODAL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NODAL expression acts as an unfavorable survival marker, although some lineages such as UCS and LUAD show a favorable association.

ACC, UCS, and DLBC are the cancer types where NODAL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.231	0.655	<.001	106	view →
UCS	OS	Median	II,III,IV	0.720	0.243	<.001	82	view →
DLBC	OS	Tertile	All	0.717	1.000	.004	45	view →
KIRP	DFS	Quartile	All	0.447	0.835	.001	42	view →
LUAD	OS	Median	III,IV	0.430	0.172	.001	41	view →
LUSC	OS	Tertile	All	0.740	0.911	.001	33	view →
COAD	OS	Quartile	All	0.809	0.423	<.001	32	view →
LGG	DFS	Median	All	0.334	0.460	.002	30	view →
MESO	OS	Median	All	0.302	0.467	.009	25	view →
SCLC	DFS	Quartile	II,III,IV	0.614	0.214	.002	18	view →
GBM	OS	Median	All	0.448	0.239	.016	15	view →
HNSC	DFS	Quartile	III,IV	0.736	0.583	.014	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

NODAL–ACC (DFS)

Open the ACC breakdown →