NODAL

Across TCGA pan-cancer cohorts, NODAL RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NODAL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NODAL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NODAL is over-expressed in tumor, although a few such as BRCA and HNSC show the opposite, repressed pattern.

KIRC, BRCA, and COAD are the cancer types where NODAL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NODAL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.345	<.001	12	view →
BRCA	All	III,IV	−0.466	<.001	6	view →
COAD	All	All	+0.489	<.001	5	view →
CHOL	All	II,III,IV	+0.710	.001	4	view →
READ	All	All	+0.677	.016	4	view →
LIHC	All	All	+0.072	<.001	3	view →
HNSC	All	IV	−0.203	.020	2	view →
LUAD	All	III,IV	−0.175	.040	2	view →
PRAD	All	All	−0.104	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NODAL–KIRC

Open the KIRC breakdown →