NODAL

Across TCGA patient cohorts, NODAL mutation is significantly associated with the RNA expression of many other genes, with 350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NODAL-associated genes across cancer lineages are OR5AO1P, C14orf177, and RNU6-784P. Each is linked with NODAL in more than 1 cancer types. Because this analysis shows association rather than direction, both NODAL-to-partner and partner-to-NODAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AO1P grouped by NODAL-low versus NODAL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NODAL→partner) and Y-score (partner→NODAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR5AO1P →	+0.106	+3.352	<.001	.004	3	2
LUSC	C14orf177 →	+0.252	+4.261	<.001	.008	3	2
LUSC	RNU6-784P →	+0.546	+5.070	<.001	.001	3	2
LUSC	RNU6-131P →	+0.252	+4.706	.006	.007	3	2
LUSC	MIR4747 →	+0.439	+4.625	<.001	.008	3	2
BLCA	BNIP3P36 →	+0.136	+5.064	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 350 associations by consensus.

OR5AO1P by NODAL expression — UCEC

Explore this box plot interactively →