NODAL

Across TCGA patient cohorts, NODAL mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible NODAL-associated genes across cancer lineages are Neutrophils, Tregs, and CD4+ Tcm. Each is linked with NODAL in more than 1 cancer types. Because this analysis shows association rather than direction, both NODAL-to-partner and partner-to-NODAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophils grouped by NODAL-low versus NODAL-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NODAL→partner) and Y-score (partner→NODAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Neutrophils →	+0.013	+3.252	.039	.044	3	2
BLCA	Tregs →	+0.063	+5.147	<.001	.003	3	1
BLCA	CD4+ Tcm →	+0.052	+3.527	<.001	.033	3	1
LIHC	Monocytes →	+0.016	+5.305	.002	.048	3	1
UCEC	Erythrocytes →	+0.039	+3.010	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Neutrophils by NODAL expression — BLCA

Explore this box plot interactively →